Two documents developed jointly by the American Society of Nuclear Cardiology (ASNC) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) highlighting myocardial perfusion positron emission tomography (PET) were e-published today in the Journal of Nuclear Cardiology. Myocardial perfusion PET imaging is increasingly used because of its high diagnostic accuracy, low radiation exposure, short image acquisition time, strong prognostic power, and quantification of myocardial blood flow. The Position Statement on the Clinical Indications for Myocardial Perfusion PET and the Updated PET Guidelines provide comprehensive guidance on appropriate indications and procedure standards for myocardial perfusion PET.